The laboratory studies the renin-angiotensin system, a collection of proteins important in blood pressure control, heart disease and renal disease. Genetic models in mice are used to investigate the basic physiology and biochemistry of the renin-angiotensin system. The lab discovered important contributions of this system to hematopoiesis, reproduction, cancer immunology and lung injury, in addition to the cardiovascular system. In particular, the lab is investigating the possibility of manipulating this system as a means of increasing immune resistance to cancer.
Cloning of angiotensin converting enzyme (ACE) and the major receptor for angiotensin II (AT1). Determination that testis ACE is the result of an intragenic, testis-specific promoter. Studies characterizing angiotensin II, the AT1 receptor and intracellular kinase activation. Creation of a mouse model null for ACE. Determination that ACE is important in hematopoiesis, reproduction and lung injury. Discovery that mice with the over expression of ACE in macrophages have an enhanced immune response to tumors.
The use of mouse genetic models to investigate the physiology and biochemistry of the renin-angiotensin system in cardiovascular disease, cancer and lung injury. The manipulation of the renin-angiotensin system as a means of increasing immune resistance to cancer.
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