It has become increasingly clear that immune cells frequently enter and survey the brain, giving rise to the field of neuroimmunology. This lab and others have shown that key immune molecules such as CD40, CD40 ligand, tumor necrosis factor-alpha, and transforming growth factor-beta play central roles in the pathoetiology of neurodegenerative diseases such as Alzheimer's disease, encephalitis, multiple sclerosis, and stroke. Genetically modified mice are programmed to develop these diseases as pre-clinical models to conduct laboratory studies aimed at targeting such neuroimmune molecules for eventual therapeutic intervention. The laboratory relys heavily on cutting edge visual analyses of brain pathology and cellular/molecular biological techniques to accomplish this goal.
Demonstrated that immunobiology plays a key role in the pathoetiology of Alzheimer's disease, and may be a viable therapeutic approach. Uncovered key roles of immune responses in viral encephalitis, stroke, and multiple sclerosis.
Developing genetically engineered pre-clinical mouse models for neurodegenerative and neuroinflammatory diseases. Investigating the function of the "stumpy" gene in mammalian ciliogenesis, postnatal neurogenesis, and tumorigenesis.
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