Research interest concerns viral pathogenesis and immunology of herpes simplex virus type 1 (HSV-1) infection. The specific areas of studies are: (1) The role of HSV-1 in herpes induced corneal scarring; (2) Vaccine development against ocular HSV-1 infection; and (3) The role of viral infection and cytokines in CNS demyelination.
1. Shown that a DNA cocktail of 5 HSV-1 glycoprotein genes is more efficacious than immunization with live virus or protein vaccine.
2. Ocular HSV-1 infection is the leading cause of corneal blindness in U.S. Have shown that HSV-1 induced eye disease is associated with HSV 1 glycoprotein K.
3. As a model for multiple sclerosis (MS), have shown that a combination of HSV-1 and IL-2 over-expression resulted in CNS demyelination.
The following NIH funded projects are in progress in the lab: (1) Improvement of vaccine efficacy against HSV. The main goal in this study is to develop a safe and effective vaccine against ocular HSV-1 infection; (2) The role of gK in HSV-1 induce corneal scarring. In this study we are testing the role of HSV-1 glycoprotein K (gK) in HSV-1 induced eye disease; and (3) The role of IL-2 and virus in optic neuritis. This study seeks to elucidate the biological and immunological mechanisms responsible for CNS demyelination in ocularly infected mice.
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