The NIH-funded lab is focused on novel cellular therapies for brain tumors and other neurological disorders using neural stem cells and immunotherapeutic modalities. The lab has a major emphasis in the development of neural stem cells from bone marrow to treat brain tumors and neurodegenerative disorders. Nanomolecules for the delivery of cytotoxic agents to brain tumors are also being investigated.
The lab has made contributions in the field of cancer stem cells in the cause of brain tumors. Recent observations have demonstrated that these cancer stem cells are chemoresistant and may be the major reason for the recurrence of these deadly tumors. Several antigen targets have been identified on glioma cells, including a T cell epitope on glioblastoma cancer stem cells. Have identified and patented a method to isolate neural stem cells from whole bone marrow and are using this technique to develop novel therapies for brain tumors and neurodegenerative diseases.
Neural stem cells have the ability to track tumor cells and areas of neurodegeneration. This property will be exploited to use neural stem cells as delivery vehicles for tumoricidal or neuroprotective agents. Actively developing a clinical protocol using neural stem cells derived from bone marrow. The lab also has a major clinical and translational effort in dendritic cell immunotherapy for glioma, specifically targeting cancer stem cells. Nanomolecules for the delivery of therapeutic agents such as neuroprotective agents and tumor cytotoxic agents are being developed.
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