Moshe Arditi, MD

Vice Chair of Research, Pediatrics

Director, PD Infectious Disease
Email:moshe.arditi@cshs.org
Phone:(310) 423-4471
Fax:(310) 423-8284

Institute Affiliation

Immunobiology Research Institute

Academic Appointments

Professor, Pediatrics

Awards and Activities

Contributing Editor, J of Clinical Investigation2006

Research Focus

Host-pathogen interactions, molecular pathogenesis of bacterial infections, role of innate and adaptive immunities in various infections and infection-induced acute and chronic inflammatory diseases, such as Allergic Asthma, Atherosclerosis, Chlamydia Pneumoniae induced Allergic sensitization and acceleration of atherosclerosis, mouse models of immune mediated Coronary arteritis models.

Research Contributions

Each of these research projects above are supported by relevant mouse models and NIH grants. Major contributions include the role of Chlamydia pneumonaie- induced acceleration of atherosclerosis and sensitization to allergic asthma and the role of TLRs and of Dendritic cells in these disease models. Funded by the National Institutes of Health (NIH) for the last 12 years and currently have 3 NIH R01 grants.

Current investigations include:

Innate Immune Mechanisms and TLRs in Mouse Models of Pneumonia, Atherosclerosis, Asthma and coronary arteritis in Kawasaki Disease . Role of Innate immune system (Toll-Like Receptors, NODs), Dendritic cells and Tregs and IL-17 in Infection-induced acceleration of atherosclerosis, sensitization for allergic asthma and colitis in mouse models.

Selected Publications

  1. Rosenkranz ME, Schulte DJ, Agle LM, Wong MH, Zhang W, Ivashkiv L, Doherty TM, Fishbein MC, Lehman TJ, Michelsen KS, Arditi M: TLR2 and MyD88 contribute to Lactobacillus casei extract-induced focal coronary arteritis in a mouse model of Kawasaki disease. Circulation, 112(19): 2966-73, 2005
  2. Naiki Y, Michelsen KS, Schröder NW, Alsabeh R, Slepenkin A, Zhang W, Chen S, Wei B, Bulut Y, Wong MH, Peterson EM, Arditi M: MyD88 is pivotal for the early inflammatory response and subsequent bacterial clearance and survival in a mouse model of Chlamydia pneumoniae pneumonia. J. Biol. Chem., 280(32): 29242-9, 2005
  3. Doherty TM, Fisher EA, Arditi M: TLR signaling and trapped vascular dendritic cells in the development of atherosclerosis. Trends Immunol., 27(5): 222-7, 2006
  4. Yilmaz A, Rowley A, Schulte DJ, Doherty TM, Schröder NW, Fishbein MC, Kalelkar M, Cicha I, Schubert K, Daniel WG, Garlichs CD, Arditi M: Activated myeloid dendritic cells accumulate and co-localize with CD3+ T cells in coronary artery lesions in patients with Kawasaki disease. Exp. Mol. Pathol., 83(1): 93-103, 2007