Shlomo Melmed, MD, FRCP
Senior Vice President, Academic AffairsDirector, Burns and Allen Research Institute
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Institute Affiliation
| Burns and Allen Research Institute |
Academic Appointments
Awards and Activities
| Endocrine Society Clinical Investigator Award | 2004 |
| Helene A. and Philip E. Hixon Chair in Investigative Medicine | 2002 |
| Royal Society of Medicine, Clinical Endocrinology Trust Medal | 1994 |
| Editor-in-Chief: Pituitary | Current |
| Editor: DeGroot and Jameson Endocrinology | Current |
| Editor-in-Chief: Endocrine Updates | Current |
| Editor: Williams Textbook of Endocrinology | 2004 |
| Editor-in-Chief: Endocrinology | 1992 - 1997 |
| President, Pituitary Society | 2002 |
| President, International Society of Endocrinology | 2004 - 2008 |
Research Focus
Molecular pathogenesis of pituitary tumors, as well as pituitary receptor signaling. Employ molecular, cellular, transgenic animal, and human tissue models to understand the biology of these commonly encountered hormone-secreting adenomas. Test pituitary receptor signaling to develop novel peptide analog treatments for these tumors secreting growth hormone, prolactin, ACTH or gonadotropins.
Research Contributions
Leader in the discovery of pituitary cell cycle genes, and developed the application of novel peptide treatments for endocrine tumors.
Current investigations include:
Transgenic models of pituitary tumors. Pituitary receptor signaling. Pituitary progenitor cells. Pituitary tumor therapeutic outcomes.
Selected Publications
- Murray RD, Kim K, Ren SG, Chelly M, Umehara Y, Melmed S: Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis. J. Clin. Invest., 114(3): 349-56, 2004
- Ben-Shlomo A, Wawrowsky KA, Proekt I, Wolkenfeld NM, Ren SG, Taylor J, Culler MD, Melmed S: Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion. J. Biol. Chem., 280(25): 24011-21, 2005
- Melmed S: Medical progress: Acromegaly. N. Engl. J. Med., 355(24): 2558-73, 2006
- Vlotides G, Cruz-Soto M, Rubinek T, Eigler T, Auernhammer CJ, Melmed S: Mechanisms for growth factor-induced pituitary tumor transforming gene-1 expression in pituitary folliculostellate TtT/GF cells. Mol. Endocrinol., 20(12): 3321-35, 2006
- Tong Y, Tan Y, Zhou C, Melmed S: Pituitary tumor transforming gene interacts with Sp1 to modulate G1/S cell phase transition. Oncogene, 26(38): 5596-605, 2007
- Chesnokova V, Zonis S, Rubinek T, Yu R, Ben-Shlomo A, Kovacs K, Wawrowsky K, Melmed S: Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Res., 67(21): 10564-72, 2007
